Genetic causes of jaw narrowness and deviation: The role of hereditary factors in the occurrence of these disorders
Narrowness and deviation of the jaw (Malocclusion) There are disorders that affect the position of the teeth and jaws in the mouth. These disorders can range from mild to severe and affect a person's appearance, chewing, speaking, and even self-confidence.. While environmental factors such as oral habits (Like thumb sucking) And trauma to the jaws can play a role in the occurrence of these disorders, the role of genetics in causing narrowness and deviation of the jaw is very significant.. This article is from the website of Dr. Behnam Khorrami (Isfahan nose surgeon _ Jaw surgeon of Isfahan), examines the genetic factors involved in these disorders.
Genetic mechanisms:
Jaw tightness and deviation is a multifactorial disorder, which means that several genes as well as environmental factors play a role in its occurrence.. No single gene alone is responsible for this disorder. Instead, a set of genes that affect the growth and development of jaw bones, teeth and facial muscles are involved in causing this disorder.. These genes can:
- bone growth: Genes involved in the growth and development of jaw bones (Mandible and maxilla) have a role, they can affect the size, shape and position of the jaws. Disturbances in these genes can lead to narrowness or deviation of the jaw.
- Size and shape of teeth: Genes affect the size, shape and number of teeth. The difference in the size of the teeth compared to the size of the jaws can lead to crowding of the teeth and as a result jaw tightness..
- The position of the teeth: Genes affect the way the teeth are placed in the jaws. Disturbances in these genes can lead to teeth deviation and as a result jaw deviation.
- Development of facial muscles: Facial muscles play an important role in the growth and development of jaws. Genes that play a role in the growth and function of these muscles can affect the position and shape of the jaws.
Related genes:
Until now, it has been difficult to identify specific genes associated with jaw stenosis and deviation. Genetic studies have shown that several genes may play a role in the disorder, but more research is needed to determine the exact role of each gene.. Some candidate genes are::
- Genes related to bone growth pathways: such as genes related to the Wnt and BMP pathways.
- Genes related to tooth development: Like the genes related to the formation of tooth enamel and tooth dentin.
- Genes related to the development of facial muscles: such as genes related to the regulation of myosin and actin.
Studies of twins and families:
Twin and family studies have shown that narrowing and deviation of the jaw has a significant hereditary component.. Identical twins (which have the same genome) More so than non-identical twins (which have different genomes) It is possible that both have narrowness and deviation of the jaw. Also, people who have a family history of narrowness and deviation of the jaw are more likely to have this disorder themselves.
Conclusion:
Jaw narrowness and deviation is a multifactorial disorder in which genetic factors play an important role. Although the identification of the specific genes associated with this disorder is still in the early stages, studies have shown that the genes affect the growth of the jawbones, the size and shape of the teeth, and the position of the teeth.. A better understanding of the role of genetics in this disorder can help to develop new diagnostic and treatment methods. Future research should focus on identifying more genes, better understanding genetic mechanisms, and developing genetic interventions to treat this disorder..
The attention of the: This article is for general information only and is not a substitute for professional medical advice.
Useful links:
Isfahan nose surgeon _ Jaw surgeon of Isfahan
Dr. Behnam Khorrami's page in the clinic 24 | Maxillofacial surgeon in Isfahan clinic 24 | Nose surgeon in Isfahan clinic 24
Dr. Behnam Khorrami, nose surgeon in Isfahan at Dr. Af | Maxillofacial surgeon in Isfahan at Dr. Af | Isfahan nose surgeon at Dr. Af